Fig. 2. (A, B): Western blot analysis of pCREB. Pt treatment may stimulate the activation of the transcription factor specifically in the dentate gyrus of 18-month-old rats. Statistical analysis performed with two-tailed unpaired t-test. N = 7. Error bars represent SEM. (C, D): Correlations between the scores obtained in the T-maze behavioral test and pCREB levels in the dentate gyrus of control (C) and Pt-treated (D) rats. N = 7.